4500-0121 Guava TUNEL Kit for Flow Cytometry

4500-0121
100 Tests  
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      Overview

      Replacement Information
      Description
      Catalogue Number4500-0121
      Trade Name
      • Guava
      DescriptionGuava TUNEL Kit for Flow Cytometry
      OverviewGuava TUNEL Assay
      for detection of late-stage apoptosis
      One of the hallmarks of late stage apoptosis, or programmed cell death, is the fragmentation of nuclear chromatin. The DNA degradation generates DNA strands with exposed 3'-hydroxyl ends.
      Quantitative fluorescence assay
      The Guava® TUNEL Assay detects apoptosis-induced DNA fragmentation through a quantitative fluorescence assay. Terminal deoxynucleotidyl transferase (TdT) catalyzes the incorporation of bromo-deoxyuridine (BrdU) residues into the fragmenting nuclear DNA at the 3'-hydroxyl ends by nicked end labeling. A TRITC-conjugated anti-BrdU antibody can then label the 3'-hydroxyl ends for detection by a Guava System. For use with all instruments. Click here for more information regarding Instrument Compatibility
      References
      Product Information
      Instrument compatibility
      • EasyCyte
      • EasyCyte Plus
      • EasyCyte Mini
      • PCA
      • PCA-96
      Applications
      ApplicationGuava TUNEL Assay for detection of late-stage apoptosis. One of the hallmarks of late stage apoptosis, or programmed cell death, is the fragmentation of nuclear chromatin.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 Tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Brochure

      Title
      Innovative Solutions for Flow Cytometry Analysis (EMD)

      Technical Info

      Title
      Application Note: Benchtop flow cytometry facilitates discrimination between induction of DNA damage, oxidative stress and protein misfolding using a novel multicell GFP reporter assay
      Monitoring apoptosis using four different assays on the Guava PCA System
      Multiplex Assay Approach to Screening Cytoactive Compounds for Cell Cycle Disruption and Apoptotic Activity on the Guava EasyCyte Plus System

      Data Sheet

      Title
      Guava Tunel Assay