4500-0450 Guava Nexin Reagent for Flow Cytometry - 100 tests

100 Tests  
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      Replacement Information
      Catalogue Number4500-0450
      Trade Name
      • Guava
      DescriptionGuava Nexin Reagent for Flow Cytometry - 100 tests
      OverviewThe Guava Nexin® Annexin V Assay offers a simple, reproducible, and reliable assessment of early apoptosis. The assay relies on the translocation of phosphatidyl serine (PS) to the outer surface of the cell membrane, an event often associated with the onset of apoptosis.
      Simple, sensitive, and reproducible
      A mix-and-read assay for monitoring externalization of PS through the binding of Annexin V to the exposed PS, the automated single-cell analysis assay is the choice for monitoring apoptosis due to its sensitivity and reproducibility. Annexin V is a calcium-dependent phospholipid binding protein with high affinity for phosphatidylserine (PS), a membrane component normally localized to the internal face of the cell membrane. Early in the apoptotic pathway, molecules of PS are translocated to the outer surface of the cell membrane where Annexin V can readily bind to them.
      Two-dye strategy
      The assay relies on a two-dye stategy: 1) Annexin V-PE to detect PS on the external membrane of apoptotic cells and 2) 7-AAD, a cell impermeant dye, as an indicator of membrane structural integrity. 7-AAD is excluded from live, healthy cells and early apoptotic cells, but permeates late-stage apoptotic and dead cells. For use with all instruments. Click here for more information regarding Instrument Compatibility
      Product Information
      • Annexin V-PE
      • 7-AAD
      • Robust Protocol
      Instrument compatibility
      • EasyCyte
      • EasyCyte Plus
      • EasyCyte Mini
      • PCA
      • PCA-96
      ApplicationThe Guava Nexin Annexin V Assay offers a simple, reproducible & reliable assessment of early apoptosis.
      Biological Information
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 Tests
      Transport Information
      Supplemental Information


      Guava Nexin Reagent for Flow Cytometry - 100 tests SDS


      Safety Data Sheet (SDS) 


      Reference overviewApplicationSpeciesPub Med ID
      Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.
      Cheng, Yan, et al.
      PLoS ONE, 7: e35104 (2012)  2012

      Show Abstract
      22496897 22496897
      Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis.
      Voisin, Thierry, et al.
      Cancer Res., 71: 3341-51 (2011)  2011

      Show Abstract
      Flow CytometryHuman21415167 21415167


      Evading Apoptosis: Cell Based Assays
      Flow Cytometry Solutions—from Core Lab to Your Lab
      Guava Cell Health Profiling

      Technical Info

      Application Note: Benchtop flow cytometry facilitates discrimination between induction of DNA damage, oxidative stress and protein misfolding using a novel multicell GFP reporter assay
      Multiplex Assay Approach to Screening Cytoactive Compounds for Cell Cycle Disruption and Apoptotic Activity on the Guava EasyCyte Plus System

      Data Sheet

      guava® easyCyte™ 8HT Flow Cytometry System

      User Guides

      Guava Nexin Reagent