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371545 | Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

371545
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₂N₅O₁₃P₃S . 4Li 94825-44-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371545-10MG
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          Glass bottle 10 mg
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          Description
          OverviewG-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
          Catalogue Number371545
          Brand Family Calbiochem®
          SynonymsGTPγ-S, 4Li
          References
          ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
          Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
          Hess, S.D., et al. 1993. Science 259, 1169.
          Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
          McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
          Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
          Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
          Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
          Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
          Product Information
          CAS number94825-44-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
          Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetG-protein-activating GTP analog
          Purity≥85% by HPLC.
          Physicochemical Information
          Cell permeableN
          ContaminantsGDP: ≤12%
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371545

          References

          Reference overview
          Iino, S., et al. 2000. FEBS Lett. 479, 46.
          Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
          Hess, S.D., et al. 1993. Science 259, 1169.
          Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
          McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
          Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
          Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
          Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
          Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2009 JSW
          SynonymsGTPγ-S, 4Li
          DescriptionG-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P3 formation in membranes.
          FormWhite solid
          CAS number94825-44-2
          Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
          Structure formula
          Purity≥85% by HPLC.
          ContaminantsGDP: ≤12%
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
          Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
          Hess, S.D., et al. 1993. Science 259, 1169.
          Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
          McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
          Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
          Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
          Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
          Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.