370677 | Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

370677
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370677-1UMOL
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          Plastic ampoule 1 umol
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          Description
          OverviewA potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.
          Catalogue Number370677
          Brand Family Calbiochem®
          SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
          References
          ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
          Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
          Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
          Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
          Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
          FormLyophilized
          Hill FormulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
          Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKG1α
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          370677

          References

          Reference overview
          Abd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
          Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
          Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
          Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
          Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

          Brochure

          Title
          Nucleotides and Bases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-July-2008 RFH
          SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
          DescriptionA potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.
          FormLyophilized
          Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO or H₂O (0.5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
          Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
          Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
          Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
          Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.