370625 | Guanabenz Acetate - CAS 23256-50-0 - Calbiochem

370625
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₈Cl₂N₄ • C₂H₄O₂ 23256-50-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370625-100MG
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          Glass bottle 250 mg
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          Description
          OverviewA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
          Catalogue Number370625
          Brand Family Calbiochem®
          Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
          References
          ReferencesTsaytler, P., et al. 2011. Science 332, 91.
          Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
          Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
          Product Information
          CAS number23256-50-0
          FormWhite powder
          Hill FormulaC₈H₈Cl₂N₄ • C₂H₄O₂
          Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          370625

          References

          Reference overview
          Tsaytler, P., et al. 2011. Science 332, 91.
          Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
          Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-August-2012 JSW
          Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
          DescriptionA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number23256-50-0
          Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesTsaytler, P., et al. 2011. Science 332, 91.
          Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
          Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.