368059 | Granzyme B Substrate II, Fluorogenic - Calbiochem

368059
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      368059-1MG
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          Plastic ampoule 1 mg
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          368059-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
              Catalogue Number368059
              Brand Family Calbiochem®
              SynonymsZ-IETD-AFC, Caspase-8 Substrate II
              References
              ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
              Product Information
              ATP CompetitiveN
              FormWhite lyophilized solid
              Hill FormulaC₃₇H₄₂F₃N₅O₁₃
              Chemical formulaC₃₇H₄₂F₃N₅O₁₃
              ReversibleN
              Applications
              Biological Information
              Primary TargetFluorogenic substrate for the detection of granzyme B and caspase-8 activity
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableN
              Emission max.
              Excitation max.
              Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              368059

              References

              Reference overview
              Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-July-2008 RFH
              SynonymsZ-IETD-AFC, Caspase-8 Substrate II
              DescriptionA fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
              FormWhite lyophilized solid
              Chemical formulaC₃₇H₄₂F₃N₅O₁₃
              Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
              Purity≥97% by HPLC
              SolubilityDMSO (1 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.

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              Categories

              Life Science Research > Inhibitors and Biochemicals