AG305 | Glutamate Receptor 2 & 3, control peptide for AB1506

AG305
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information
      Description
      Catalogue NumberAG305
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionGlutamate Receptor 2 & 3, control peptide for AB1506
      OverviewPeptide from the carboxy terminus of rat GluR2.
      Alternate Names
      • GluR2/3
      References
      Product Information
      PresentationLiquid in water. Contains no preservative.
      Applications
      Key Applications
      • Cell Function Assay
      Application NotesFor use in blocking the reactivity of AB1506.

      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1.0 mg/mL
      Entrez Gene Number
      Entrez Gene SummaryGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
      Gene Symbol
      • GRIA2
      • GluR-B
      • gluR-B
      • GluR-2
      • HBGR2
      • GluR-K2
      • GLUR2
      • GLURB
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42262 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
      SIZE: 883 amino acids; 98821 Da
      SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
      SIMILARITY: SwissProt: P42262 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      GLUTAMATE RECEPTOR 2/3 (GluR2/3) CONTROL PEPTIDE - 2420479 2420479
      GLUTAMATE RECEPTOR 2/3 (GluR2/3) CONTROL PEPTIDE - 2454729 2454729

      References

      Reference overviewPub Med ID
      Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse.
      Olga Shevtsova,Beulah Leitch
      Brain research  1427  2012

      Show Abstract
      22055455 22055455
      Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochlea.
      M J Drescher,D G Drescher,K M Khan,J S Hatfield,N A Ramakrishnan,M D Abu-Hamdan,L A Lemonnier
      Neuroscience  142  2006

      Show Abstract
      16876955 16876955

      Data Sheet

      Title
      Glutamate Receptor 2 & 3, control peptide for AB1506 - Data Sheet