Key Specifications Table
|Empirical Formula||CAS #|
Pricing & Availability
An invalid quantity was specified. The product quantity has been adjusted.
|345887-5MG||Plastic ampoule||5 mg||
|Overview||A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).|
|Synonyms||(Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, HAT Inhibitor VI|
|References||Fukuda, I., et al. 2009. Chem. Biol. 16, 133.|
|Structure formula Image|
|Application||Ginkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.|
|Purity||≥98% by HPLC|
|Safety Information according to GHS|
|R Phrase||R: 36/37/38
Irritating to eyes, respiratory system and skin.
|S Phrase||S: 26
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
|Product Usage Statements|
|Storage and Shipping Information|
|Ship Code||Ambient Temperature Only|
|Protect from Light||Protect from light|
|Do not freeze||Ok to freeze|
|Special Instructions||Following intitial thaw, aliquot and freeze (-20°C).|
|Packaged under inert gas||Packaged under inert gas|
|Fukuda, I., et al. 2009. Chem. Biol. 16, 133.|