345834 Genistein, Soybean - CAS 446-72-0 - Calbiochem

345834
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₅ 446-72-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345834-20MG
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          Glass bottle 20 mg
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          345834-50MG
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              Plastic ampoule 50 mg
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              Description
              OverviewA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
              Catalogue Number345834
              Brand Family Calbiochem®
              Synonyms4ʹ,5,7-Trihydroxyisoflavone
              References
              ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
              Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
              Wei, H., et al. 1995. Carcinogenesis 17, 73.
              Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
              Migita, K., et al. 1994. J. Immunol. 153, 3457.
              Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
              Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
              Hill, T.D., et al. 1990. Science 248, 1660.
              Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
              Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
              Product Information
              CAS number446-72-0
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₅H₁₀O₅
              Chemical formulaC₁₅H₁₀O₅
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetEGFR kinase
              Primary Target IC<sub>50</sub>2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSNR2392000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              345834

              References

              Reference overview
              Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
              Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
              Wei, H., et al. 1995. Carcinogenesis 17, 73.
              Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
              Migita, K., et al. 1994. J. Immunol. 153, 3457.
              Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
              Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
              Hill, T.D., et al. 1990. Science 248, 1660.
              Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
              Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure

              Citations

              Title
            • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision16-April-2010 JSW
              Synonyms4ʹ,5,7-Trihydroxyisoflavone
              DescriptionA cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits exogenous substrate phosphorylation by EGFR kinase and pp60v-src with similar potencies (IC50 = 20-25 µM). Has only a trivial effect on PKC and PKA (IC50 >350 µM). Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. Blocks oxidative DNA damage in vitro.
              FormWhite solid
              CAS number446-72-0
              RTECSNR2392000
              Chemical formulaC₁₅H₁₀O₅
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (200 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 4391
              ReferencesConstantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
              Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
              Wei, H., et al. 1995. Carcinogenesis 17, 73.
              Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
              Migita, K., et al. 1994. J. Immunol. 153, 3457.
              Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
              Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
              Hill, T.D., et al. 1990. Science 248, 1660.
              Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
              Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
              Citation
            • Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.