506216 Gap Junction Enhancer, PQ7 - Calbiochem

506216
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₁₉F₃N2O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06216.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
          Catalogue Number506216
          Brand Family Calbiochem®
          References
          ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
          Shishido, S.N., et al. 2012. PLos One. 7,e444963.
          Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
          Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
          Product Information
          FormTan powder
          Hill FormulaC₂₃H₁₉F₃N2O₃
          Chemical formulaC₂₃H₁₉F₃N2O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target IC<sub>50</sub>100 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Shishido, S.N., et al. 2013. PLos One. 8, e67174.
          Shishido, S.N., et al. 2012. PLos One. 7,e444963.
          Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
          Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-December-2013 JSW
          DescriptionA cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
          FormTan powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₁₉F₃N2O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
          Shishido, S.N., et al. 2012. PLos One. 7,e444963.
          Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
          Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.