345701 | Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem

345701
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₈H₄₄O₈ 2752-65-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345701-25MG
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          Alu drum 25 mg
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          Description
          OverviewA cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).
          Catalogue Number345701
          Brand Family Calbiochem®
          SynonymsGuttic Acid, β-Guttiferin
          References
          ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
          Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
          Asano, J., et al. 1996. Phytochemistry 41, 815.
          Product Information
          CAS number2752-65-0
          ATP CompetitiveN
          FormAmorphous orange solid
          Hill FormulaC₃₈H₄₄O₈
          Chemical formulaC₃₈H₄₄O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCaspase activator and an apoptosis inducer
          Primary Target IC<sub>50</sub>MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSPB9268200
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345701

          References

          Reference overview
          Prasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
          Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
          Asano, J., et al. 1996. Phytochemistry 41, 815.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-July-2017 JSW
          SynonymsGuttic Acid, β-Guttiferin
          DescriptionA cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
          FormAmorphous orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2752-65-0
          RTECSPB9268200
          Chemical formulaC₃₈H₄₄O₈
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 4361
          ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
          Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
          Asano, J., et al. 1996. Phytochemistry 41, 815.