361562 | GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem

361562
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₀ClN₅OS 1139875-74-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361562-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC50 = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC50 = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC50 = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.
          Catalogue Number361562
          Brand Family Calbiochem®
          Synonyms2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone
          References
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Product Information
          CAS number1139875-74-3
          FormWhite solid
          Hill FormulaC₂₀H₂₀ClN₅OS
          Chemical formulaC₂₀H₂₀ClN₅OS
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361562

          References

          Reference overview
          Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          Synonyms2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone
          DescriptionA cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC50 = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC50 = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC50 = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1139875-74-3
          Chemical formulaC₂₀H₂₀ClN₅OS
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.