361558 GSK-3 Inhibitor XV - Calbiochem

361558
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₅H₁₄BrN₃O₆Ru

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361558-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewThe racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
          Catalogue Number361558
          Brand Family Calbiochem®
          References
          ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
          Product Information
          ATP CompetitiveY
          DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania. Sold under license of U.S. Patent 7,488,817.
          FormPurple solid
          Hill FormulaC₂₅H₁₄BrN₃O₆Ru
          Chemical formulaC₂₅H₁₄BrN₃O₆Ru
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationGSK-3 Inhibitor XV, is a cell-permeable, reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively).
          Biological Information
          Primary TargetGSK-3
          Primary Target IC<sub>50</sub>0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361558

          References

          Reference overview
          Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.

          Brochure

          Title
          Biologics 35.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-February-2008 JSW
          DescriptionThe racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
          FormPurple solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₁₄BrN₃O₆Ru
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (6 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.