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371706 | GPR40 Agonist - CAS 885101-89-3 - Calbiochem

371706
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₁NO₃ 885101-89-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371706-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC50 ~50 nM) with much reduced activity towards family members GPR120 (EC50 ~3.5 µM), GPR41/GPR43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
          Catalogue Number371706
          Brand Family Calbiochem®
          Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
          References
          ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
          Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
          Product Information
          CAS number885101-89-3
          FormLight yellow solid
          Hill FormulaC₂₂H₂₁NO₃
          Chemical formulaC₂₂H₂₁NO₃
          Structure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371706

          References

          Reference overview
          McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
          Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-January-2011 RFH
          Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
          DescriptionA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40 (EC50 ~50 nM) with much reduced activity towards family members GRP120 (EC50 ~3.5 µM), GRP41/GRP43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number885101-89-3
          Chemical formulaC₂₂H₂₁NO₃
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
          Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.