345762 | GDF-8/Myostatin, Human, Mouse, Rat, Recombinant

345762
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥80% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345762-10UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 μg
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          Description
          OverviewRecombinant, human mouse rat growth differentiation factor 8 (GDF-8) consisting of amino acids 268-376 and expressed in NS0-derived murine myeloma cells. GDF-8 is expressed in developing and adult skeletal muscle and is 100% identical to mature human, rat, mouse, and cow at the amino acid sequence level. Useful for the inhibition of preadipocyte differentiation to adipocytes.
          Catalogue Number345762
          Brand Family Calbiochem®
          SynonymsMyostatin
          References
          ReferencesKim, H.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 902.
          Lee, S.J., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9306.
          Sharma, M., et al. 1999. J. Cell Physiol. 180, 1.
          McPherron, A.C., et al. 1997. Nature 387, 83.
          Storm, E.E., et al. 1994. Nature 368, 639.
          Product Information
          FormSolid
          FormulationLyophilized from 0.2 µm filtered Acetonitrile, TFA, BSA.
          Applications
          ApplicationGDF-8/Myostatin, Human, Mouse, Rat, Recombinant, consists of amino acids 268-376 and is expressed in NS0-derived murine myeloma cells. Useful for inhibiting preadipocyte differentiation to adipocytes.
          Biological Information
          Biological activityHemoglobin Expression:
          ED₅₀ = 2-10 ng/ml as measured by induction of hemoglobin expression in k562 human chronic myelogenous leukemia cells.

          Elongation of Animal Caps:
          Optimal Elongation of animal caps from Xenpus blastulae.
          Purity≥80% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1.0 EU per/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345762

          References

          Reference overview
          Kim, H.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 902.
          Lee, S.J., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9306.
          Sharma, M., et al. 1999. J. Cell Physiol. 180, 1.
          McPherron, A.C., et al. 1997. Nature 387, 83.
          Storm, E.E., et al. 1994. Nature 368, 639.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2011 RFH
          SynonymsMyostatin
          DescriptionRecombinant, human mouse rat growth differentiation factor 8 (GDF-8) consisting of amino acids 268-376 and expressed in NS0-derived murine myeloma cells. GDF-8 is expressed in developing and adult skeletal muscle and is 100% identical to mature human, rat, mouse, and cow at the amino acid sequence level. Useful for the inhibition of preadipocyte differentiation to adipocytes.
          FormSolid
          FormulationLyophilized from 0.2 µm filtered Acetonitrile, TFA, BSA.
          Purity≥80% by SDS-PAGE
          ContaminantsEndotoxin: <1.0 EU per/µg protein
          Biological activityHemoglobin Expression:
          ED₅₀ = 2-10 ng/ml as measured by induction of hemoglobin expression in k562 human chronic myelogenous leukemia cells.

          Elongation of Animal Caps:
          Optimal Elongation of animal caps from Xenpus blastulae.
          SolubilityReconstitute to 100 µg/ml in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, H.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 902.
          Lee, S.J., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9306.
          Sharma, M., et al. 1999. J. Cell Physiol. 180, 1.
          McPherron, A.C., et al. 1997. Nature 387, 83.
          Storm, E.E., et al. 1994. Nature 368, 639.