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345731 | GDF-5, Mouse, Recombinant

345731
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥95% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345731-50UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 50 μg
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          Description
          OverviewRecombinant, mouse growth differentiation factor 5 (GDF-5) consisting of amino acids 376-495, expressed in E. coli with and without an N-terminal methionine. GDF-5, a member of the bone morphogenetic protein family, is involved in regulation of myogenesis, bone morphogenesis, neuron differentiation and survival, and chondrogenesis regulation.
          Catalogue Number345731
          Brand Family Calbiochem®
          SynonymsCartilage-derived morphogenetic protein 1 (CDMP-1)
          References
          ReferencesSettle, S.H., Jr., et al. 2003. Dev. Biol. 254, 116.
          Massague, J., et al. 2000. Genes and Dev. 14, 627.
          FrancisWest, P.H., et al. 1999.
          Development 126, 1035. Inada, M., et al. 1996. BBRC 222, 317.
          Nishitoh, H., et al. 1996. J. Biol. Chem. 271, 21345.
          Storm, E.E., et al. 1994. Nature 368, 639.
          Product Information
          FormSolid
          FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, BSA.
          Applications
          ApplicationGDF-5, Mouse, Recombinant, consists of amino acids 376-495 and is expressed in E. coli with and without an N-terminal methionine. Involved in myogenesis, bone morphogenesis & neuron differentiation.
          Biological Information
          Biological activityED₅₀ = 1-4 µg/ml as measured by induction of alkaline phosphatase production by ATDC5 mouse chondrogenic cells. (Nakamura, K. et al. 1999. Exp. Cell Res. 250, 351.)
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345731

          References

          Reference overview
          Settle, S.H., Jr., et al. 2003. Dev. Biol. 254, 116.
          Massague, J., et al. 2000. Genes and Dev. 14, 627.
          FrancisWest, P.H., et al. 1999.
          Development 126, 1035. Inada, M., et al. 1996. BBRC 222, 317.
          Nishitoh, H., et al. 1996. J. Biol. Chem. 271, 21345.
          Storm, E.E., et al. 1994. Nature 368, 639.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2011 RFH
          SynonymsCartilage-derived morphogenetic protein 1 (CDMP-1)
          DescriptionRecombinant, mouse growth differentiation factor 5 (GDF-5) consisting of amino acids 376-495, expressed in E. coli with and without an N-terminal methionine. GDF-5, a member of the bone morphogenetic protein family, is involved in regulation of myogenesis, bone morphogenesis, neuron differentiation and survival, and chondrogenesis regulation.
          FormSolid
          FormulationLyophilized from 0.2 µm filter-sterilized Acetonitrile, TFA, BSA.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Biological activityED₅₀ = 1-4 µg/ml as measured by induction of alkaline phosphatase production by ATDC5 mouse chondrogenic cells. (Nakamura, K. et al. 1999. Exp. Cell Res. 250, 351.)
          SolubilityReconstitute to 150 µg/ml in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSettle, S.H., Jr., et al. 2003. Dev. Biol. 254, 116.
          Massague, J., et al. 2000. Genes and Dev. 14, 627.
          FrancisWest, P.H., et al. 1999.
          Development 126, 1035. Inada, M., et al. 1996. BBRC 222, 317.
          Nishitoh, H., et al. 1996. J. Biol. Chem. 271, 21345.
          Storm, E.E., et al. 1994. Nature 368, 639.