365252 Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem

365252
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₂₆N₄O₄ · HCl 287935-76-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      365252-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC). Inhibits protein kinase A (IC50 = 510 nM), protein kinase G (IC50 = 4.8 µM), and myosin light chain kinase (IC50 = 120 nM) at much higher concentrations.
          Catalogue Number365252
          Brand Family Calbiochem®
          SynonymsMLCK Inhibitor III
          References
          ReferencesKleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.
          Product Information
          CAS number287935-76-6
          ATP CompetitiveY
          FormAmber solid
          Hill FormulaC₂₇H₂₆N₄O₄ · HCl
          Chemical formulaC₂₇H₂₆N₄O₄ · HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>4 nM against rat brain PKC
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          365252

          References

          Reference overview
          Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.

          Brochure

          Title
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsMLCK Inhibitor III
          DescriptionA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of rat brain protein kinase C (IC50 = 4 nM) versus myosin light chain kinase (IC50 = 0.12 µM), protein kinase A (IC50 = 510 nM), and protein kinase G (IC50 = 4.8 µM).
          FormAmber solid
          CAS number287935-76-6
          Chemical formulaC₂₇H₂₆N₄O₄ · HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.