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14-441M | Fyn Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-441) and in bulk (cat# 14-441-K).
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      Replacement Information
      Catalogue Number14-441M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFyn Protein, active, 250 µg
      OverviewN-Terminal His6-tagged, recombinant, full-length, human Fyn.
      Product Information
      ApplicationActive, N-Terminal His6-tagged, recombinant, full-length, human Fyn. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman Fyn, expressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
      Gene Symbol
      • FYN
      • p59-Fyn
      • MGC45350
      • SYN
      • SLK
      Protein TargetFyn
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
      COFACTOR: Manganese.
      SIZE: 537 amino acids; 60762 Da
      SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.
      SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
      TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
      SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight61.8kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of the Src substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-441) and in bulk (cat# 14-441-K).
      Transport Information
      Supplemental Information

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-441 Fyn Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases