344281 Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

344281
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₃NO₈ • HCl 138605-00-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344281-5MG
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          5 mg
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          Description
          OverviewA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
          Catalogue Number344281
          Brand Family Calbiochem®
          Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
          References
          ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
          Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
          Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
          Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
          Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
          Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
          Shafiq, J., et al. 1992. Circ. Res. 71, 70.
          Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
          Product Information
          CAS number138605-00-2
          FormWhite solid
          Hill FormulaC₂₇H₄₃NO₈ • HCl
          Chemical formulaC₂₇H₄₃NO₈ • HCl
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 26/27/28-62-63

          Very toxic by inhalation, in contact with skin and if swallowed.
          Possible risk of impaired fertility.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-24/25-36/37/39-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344281

          References

          Reference overview
          Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
          Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
          Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
          Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
          Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
          Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
          Shafiq, J., et al. 1992. Circ. Res. 71, 70.
          Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2010 RFH
          Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
          DescriptionA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number138605-00-2
          Chemical formulaC₂₇H₄₃NO₈ • HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Highly Toxic
          ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
          Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
          Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
          Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
          Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
          Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
          Shafiq, J., et al. 1992. Circ. Res. 71, 70.
          Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.