344220 | Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem

344220
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₆₁H₆₅N₁₅O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344220-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 5 mg
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          Description
          OverviewA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
          Catalogue Number344220
          Brand Family Calbiochem®
          SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
          References
          ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₁H₆₅N₁₅O₆
          Chemical formulaC₆₁H₆₅N₁₅O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)
          Primary Target IC<sub>50</sub>230 nM for FPRL1 Agonist
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344220

          References

          Reference overview
          Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2008 RFH
          SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
          DescriptionA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₆₁H₆₅N₁₅O₆
          Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.