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852068 | Fmoc-(FmocHmb)Lys(Boc)-OH

852068
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Hill FormulaMolar Mass
      166881-56-7 C₄₉H₅₀N₂O₁₀ 826.93 g/mol

      Pricing & Availability

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      8520680001
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          Plastic bottle 1 g
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          8520680005
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              Plastic bottle 5 g
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              Description
              Catalogue Number852068
              Replaces04-12-1148
              Brand Family Novabiochem®
              Alternate Names
              • N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-N-ε-t.-butoxycarbonyl-L-lysine
              Background InformationHmb protection of amide bonds has been shown to inhibit aggregation of 'difficult' peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxy group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].

              The product number for this product was previously 04-12-1148.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number166881-56-7
              Hill FormulaC₄₉H₅₀N₂O₁₀
              Molar Mass826.93 g/mol
              HS Code2924 29 98
              Structure formula Image
              Applications
              ApplicationFmoc-(FmocHmb)Lys(Boc)-OH Novabiochem®. CAS 166881-56-7, molar mass 826.93 g/mol.
              Biological Information
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 2 water endangering
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Colour (visual)white to slight yellow to beige
              Appearance of substance (visual)powder
              Identity (IR)passes test
              Enantiomeric purity≥ 99.5 % (a/a)
              Purity (TLC(157A))≥ 98 %
              Purity (TLC(157B))≥ 98 %
              Assay (HPLC, area%)≥ 97.0 % (a/a)
              Solubility (1 mmole in 2 ml DMF)clearly soluble
              For TLC-Systems see our General Catalog

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              8520680001 Plastic bottlePDF Specification Document
              8520680005 Plastic bottlePDF Specification Document

              Brochure

              Title
              Novabiochem Letters 03/05

              Citations

              Title
              • [1] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
              • [2] C. Hyde, et al. (1994) Int. J. Peptide Protein Res., 43, 431.
              • [3] L. C. Packman, et al. (1994) Pept. Res., 7, 125.
              • [4] T. Johnson, et al. (1994) Tetrahedron Lett., 35, 463.
              • [5] R. G. Simmonds (1996) Int. J. Peptide Protein Res., 47, 36.
              • [6] T. Johnson, et al. (1995) Lett. Pept. Sci., 1, 11.
              • [7] M. Quibell, et al. (1995) J. Am. Chem. Soc., 117, 11656.
              • [8] M. Quibell, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 1227.
              • [9] M. Quibell, et al. (1994) Tetrahedron Lett., 35, 2237.
              • [10] M. Quibell, et al. (1994) J. Org. Chem., 59, 1745.
              • [11] M. Quibell, et al. (1995) J. Chem. Soc., Perkin Trans. 1, 2019.
              • [12] M. Quibell, et al. (1994) J. Chem. Soc., Chem. Commun., 2343.
              • [13] L. C. Packman (1995) Tetrahedron Lett., 36, 7523.
              • [14] J. Offer, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 175.
              • [15] W. R. Sampson, et al. (1999) J. Peptide Sci., 5, 403.