508048 Filastatin - Calbiochem

Filastatin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone

508048
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₈ClN₃O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08048.0001
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          		 Glass bottle 25 mg
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          Description
          OverviewA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
          Catalogue Number508048
          Brand Family Calbiochem®
          Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
          References
          ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
          Product Information
          FormYellow powder
          Hill FormulaC₁₈H₁₈ClN₃O₃
          Chemical formulaC₁₈H₁₈ClN₃O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-November-2013 JSW
          Synonyms1-(3-Chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine, (3-Chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
          DescriptionA cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₈ClN₃O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesFazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 13594.