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Description
Overview
A cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA110, 13594.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable, nontoxic benzoyl-nitrophenylpiperazine compound with anti-fungal properties. Prevents the adhesion of multiple pathogenic Candida species to polystyrene surfaces and human cells (IC50 = 3 µM in A549 cells). Does not affect the viability of human cells even at high concentrations (~250 µM). Also effective, but to slightly lower extent, when added to cells following their adhesion. Keeps cells dispersed in the media and blocks the formation of hyphae (~2.5 µM). Also reported to block the transcriptional induction of the HWP1 promoter and is believed to act downstream of Efg1 transcription factor. Exhibits antifungal activity in a nematode model (C. elegans) and increases the life span of Candida infected worms. Also reported to alter biofilm morphology in a murine model of vulvovaginal candidiasis.
Form
Yellow powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₈H₁₈ClN₃O₃
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (100 mg/ml)
Storage
+2°C to +8°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Fazly, A., et al. 2013. Proc. Natl. Acad. Sci. USA110, 13594.