341600 | Fibrinogen, Fragment D, Human Plasma

341600
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341600-200UG
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          Plastic ampoule 200 μg
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          Description
          OverviewNative fibrinogen fragment D from human plasma prepared by plasmin digestion of purified fibrinogen followed by preparative electrophoresis. Thermolabile core fragment of fibrinogen. Complete proteolysis of a single fibrinogen molecule produces two D and one E fragments. The D and E fragments have no common antigenic determinants; therefore, no cross-reaction occurs. Reported to increase endothelial membrane permeability to albumin.
          Catalogue Number341600
          Brand Family Calbiochem®
          References
          ReferencesSpraggon, G., et al. 1997. Nature 389, 455.
          Stirk, C.M., et al. 1993. Atherosclerosis 103, 159.
          Vogel, P., et al. 1993. Eur. Surg. Res. 25, 83.
          Azpiazu, I., and Chapman, D. 1992. Biochim. Biophys. Acta 1119, 268.
          Thompson, W.D., et al. 1992. J. Pathol. 168, 47.
          Fisher, E.G., et al. 1991. Haemostasis 21, 141.
          Ge, M., et al. 1991. Am. J. Physiol. 261, L283.
          Product Information
          FormLyophilized
          FormulationLyophilized from 400 mM glycine, 150 mM NaCl.
          Applications
          ApplicationFibrinogen fragment D is a thermolabile native human plasma protein prepared by digestion of purified fibrinogen followed by preparative electrophoresis.
          Biological Information
          Puritysingle band by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          ContaminantsFragment E: ≤1%
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 4 h at 20°C or for up to 8 h at 4°C or for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341600

          References

          Reference overview
          Spraggon, G., et al. 1997. Nature 389, 455.
          Stirk, C.M., et al. 1993. Atherosclerosis 103, 159.
          Vogel, P., et al. 1993. Eur. Surg. Res. 25, 83.
          Azpiazu, I., and Chapman, D. 1992. Biochim. Biophys. Acta 1119, 268.
          Thompson, W.D., et al. 1992. J. Pathol. 168, 47.
          Fisher, E.G., et al. 1991. Haemostasis 21, 141.
          Ge, M., et al. 1991. Am. J. Physiol. 261, L283.

          Brochure

          Title
          Coagulation Factors Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          DescriptionNative fibrinogen fragment D from human plasma prepared by plasmin digestion of purified fibrinogen followed by preparative electrophoresis. Thermolabile fragment. Complete proteolysis of a single fibrinogen molecule produces two D and one E fragments. Fragment D has been shown to increase endothelial monolayer permeability and to decrease polymorphonuclear leukocyte adhesion to endothelial cells. The D and E fragments have no common antigenic determinants; therefore, no cross-reactivity occurs.
          FormLyophilized
          FormulationLyophilized from 400 mM glycine, 150 mM NaCl.
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Puritysingle band by SDS-PAGE
          ContaminantsFragment E: ≤1%
          SolubilitySterile distilled H₂O (200 µg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 4 h at 20°C or for up to 8 h at 4°C or for up to 3 months at -70°C.
          Toxicity Standard Handling
          ReferencesSpraggon, G., et al. 1997. Nature 389, 455.
          Stirk, C.M., et al. 1993. Atherosclerosis 103, 159.
          Vogel, P., et al. 1993. Eur. Surg. Res. 25, 83.
          Azpiazu, I., and Chapman, D. 1992. Biochim. Biophys. Acta 1119, 268.
          Thompson, W.D., et al. 1992. J. Pathol. 168, 47.
          Fisher, E.G., et al. 1991. Haemostasis 21, 141.
          Ge, M., et al. 1991. Am. J. Physiol. 261, L283.