341501 | FeTMPyP - Calbiochem

341501
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₄H₃₆Cl₅FeN₈

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341501-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewCatalyzes the isomerization of peroxynitrite (ONOO) to nitrate (NO3) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals (O2·). Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH·) radicals. FeTMPyP can also serve as a potential for drug detoxification of reactive oxygen species (ROS).
          Catalogue Number341501
          Brand Family Calbiochem®
          Synonyms5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, FeIIITMPyP(Cl)
          References
          ReferencesLee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
          Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
          Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
          Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.
          Product Information
          ATP CompetitiveN
          FormBrown solid
          Hill FormulaC₄₄H₃₆Cl₅FeN₈
          Chemical formulaC₄₄H₃₆Cl₅FeN₈
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPeroxynitrite (ONOO-)
          Primary Target IC<sub>50</sub>Kcat = 2.2 x 106 M-1s-1 in catalyzing the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions
          Purity≥90% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341501

          References

          Reference overview
          Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
          Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
          Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
          Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          Synonyms5,10,15,20-Tetrakis(N-methyl-4ʹ-pyridyl)porphinato Iron (III) Chloride, FeIIITMPyP(Cl)
          DescriptionCatalyzes the isomerization of peroxynitrite (ONOO-) to nitrate (NO3-) under physiological conditions and at realistic dose-derived concentrations (Kcat = 2.2 x 106 M-1s-1). Effectively prevents the oxidation of lipid components by peroxynitrite. Also decomposes superoxide radicals (O2) catalytically. Irradiation of the aqueous solution at 335 nm releases hydroxyl (OH) radicals. FeTMPyP can also serve as a potential drug for reactive oxygen species (ROS) detoxification.
          FormBrown solid
          Chemical formulaC₄₄H₃₆Cl₅FeN₈
          Structure formulaStructure formula
          Purity≥90% by TLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, J., et al. 1998. J. Am. Chem. Soc. 120, 7493.
          Hunt, J.A., et al. 1997. Chem. Biol. 4, 845.
          Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
          Stern, M.K., et al. 1996. J. Am. Chem. Soc. 118, 8735.
          Faraggi, M., et al. 1984. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 46, 703.