341305 | Fasentin - CAS 392721-37-8 - Calbiochem

341305
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341305-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED50 = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.
          Catalogue Number341305
          Brand Family Calbiochem®
          SynonymsGlucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
          References
          ReferencesWood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
          Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.
          Product Information
          CAS number392721-37-8
          FormOff-white solid
          Hill FormulaC₁₁H₉ClF₃NO₂
          Chemical formulaC₁₁H₉ClF₃NO₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341305

          References

          Reference overview
          Wood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
          Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          SynonymsGlucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
          DescriptionA cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED50 = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number392721-37-8
          Chemical formulaC₁₁H₉ClF₃NO₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.
          Toxicity Standard Handling
          ReferencesWood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
          Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.