341280 Factor I, Human

341280
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341280-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewNative factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (α) and 38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.
          Catalogue Number341280
          Brand Family Calbiochem®
          SynonymsC3b/C4b Inactivator
          References
          ReferencesSolol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
          Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
          Product Information
          FormLiquid
          FormulationIn PBS, pH 7.2.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          ContaminantsIgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin: ≤trace amounts
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341280

          References

          Reference overview
          Solol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
          Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          SynonymsC3b/C4b Inactivator
          DescriptionNative factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of ~50 kDa (α) and ~38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I mediated cleavage of C4b.
          FormLiquid
          FormulationIn PBS, pH 7.2.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥95% by SDS-PAGE
          ContaminantsIgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin: ≤trace amounts
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesSolol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
          Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.