344597 FTY720

344597
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₃₃NO₂ • HCl 162359-56-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344597-10MG
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          Glass bottle 10 mg
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          Description
          Overview

          A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
          Catalogue Number344597
          Brand Family Calbiochem®
          Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
          References
          ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
          Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
          Mandala, S., et al. 2002. Science 296, 346.
          Chiba, K., et al. 1998. J. Immunol. 160, 5037.
          Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
          Product Information
          CAS number162359-56-0
          FormSolid
          Hill FormulaC₁₉H₃₃NO₂ • HCl
          Chemical formulaC₁₉H₃₃NO₂ • HCl
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344597

          References

          Reference overview
          Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
          Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
          Mandala, S., et al. 2002. Science 296, 346.
          Chiba, K., et al. 1998. J. Immunol. 160, 5037.
          Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
          DescriptionA cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number162359-56-0
          Chemical formulaC₁₉H₃₃NO₂ • HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
          Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
          Mandala, S., et al. 2002. Science 296, 346.
          Chiba, K., et al. 1998. J. Immunol. 160, 5037.
          Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.