344550 | FTI-276 - Calbiochem

344550
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₂₇N₃O₃S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344550-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
          Catalogue Number344550
          Brand Family Calbiochem®
          SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
          References
          ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₂₁H₂₇N₃O₃S₂
          Chemical formulaC₂₁H₂₇N₃O₃S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFTase in vitro
          Primary Target IC<sub>50</sub>500 pM against FTase in vitro
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344550

          References

          Reference overview
          Lantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
          DescriptionA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₂₇N₃O₃S₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
          Toxicity Standard Handling
          ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
          Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
          Sun, J., et al. 1995. Cancer Res. 55, 4243.