A part of MilliporeSigma

ABS992 | FKBP-8 Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Serum Polyclonal Antibody
      Catalogue NumberABS992
      DescriptionFKBP-8 Antibody
      Alternate Names
      • Peptidyl-prolyl cis-trans isomerase FKBP8
      • PPIase FKBP8
      • 38 kDa FK506-binding protein
      • 38 kDa FKBP
      • FKBP-38
      • hFKBP38
      • FK506-binding protein 8
      • FKBP-8
      • FKBPR38
      • Rotamase
      Background InformationFKBP-8, also known as Peptidyl-prolyl cis-trans isomerase PPIase FKBP8, FKBP8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, is encoded by the gene name FKBP8 and FKBP38. FKBP-8 is in constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Recent studies have shown that FKBP-8 may act as a chaperone for BCL2, by targeting BCL2 to the mitochondria and modulating its phosphorylation state. Furthermore, the BCL2/FKBP8/calmodulin/calcium complex may play a role in the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. FKBP-8 is expressed widely, with highest levels detected in brain. FKBP-8 is also highly abundant in the retina.
      Product Information
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      ApplicationThis FKBP-8 antibody is validated for use in WB, IH for the detection of FKBP-8.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A representative lot detected FKBP-8 in HeLa transfected with myc-FKBP38 and HEK293 cell lysate (Zou, H., et al. (2013). JBC. 1-9).
      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FKBP-8 in human cerebral cortex and human thalamus tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminus of human FKBP-8.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FKBP8
      • FKBP38
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~60 kDa observed. The calculated molecular weight is 44 kDa, however FKBP-8 has been shown at ~53-62 kDa most likely due to post-translational modification.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FKBP-8 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information