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341220 | Exo1 - CAS 75541-83-2 - Calbiochem

341220
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂FNO₃ 75541-83-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341220-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies.
          Catalogue Number341220
          Brand Family Calbiochem®
          Synonyms2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
          References
          ReferencesFeng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.
          Product Information
          CAS number75541-83-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₁₂FNO₃
          Chemical formulaC₁₅H₁₂FNO₃
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetGolgi ARF1 GTPase
          Primary Target IC<sub>50</sub>20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341220

          References

          Reference overview
          Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          Synonyms2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
          DescriptionA cell-permeable methylanthranilate analog that reversibly blocks vesicular traffic from the ER to the Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and re-directing the traffic back to the ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor, Brefeldin A (BFA) (Cat. No. 203729), the effects appear to be limited to the Golgi, as no effects are detected on endocytic organelles, such as endosomes and trans-Golgi network (TGN). The inhibitory mechanism and target(s) appear to be different from those of BFA, thus making it a valuable alternative that complements BFA in membrane trafficking studies.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number75541-83-2
          Chemical formulaC₁₅H₁₂FNO₃
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml), DMF (25 mg/ml), Methanol (5 mg/ml), or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesFeng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.