341205 Etoposide - CAS 33419-42-0 - Calbiochem

341205
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₃₂O₁₃ 33419-42-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341205-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
          Catalogue Number341205
          Brand Family Calbiochem®
          SynonymsVP-16
          References
          ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
          Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
          Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
          Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
          Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
          Product Information
          CAS number33419-42-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₃₂O₁₃
          Chemical formulaC₂₉H₃₂O₁₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
          Biological Information
          Primary Targettopoisomerase 2
          Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
          Purity>97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKC0190000
          Safety Information
          R PhraseR: 22-45

          Harmful if swallowed.
          May cause cancer.
          S PhraseS: 26-36/37/39-45-53

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341205

          References

          Reference overview
          De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
          Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
          Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
          Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
          Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-May-2008 RFH
          SynonymsVP-16
          DescriptionA cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
          FormWhite solid
          CAS number33419-42-0
          RTECSKC0190000
          Chemical formulaC₂₉H₃₂O₁₃
          Structure formulaStructure formula
          Purity>97% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 3886
          ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
          Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
          Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
          Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
          Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.