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329600 | Erastin - CAS 571203-78-6 - Calbiochem

329600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₃₁ClN₄O₄ 571203-78-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      329600-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
          Catalogue Number329600
          Brand Family Calbiochem®
          Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
          References
          ReferencesYagoda, N., et al. 2007. Nature 447, 864.
          Product Information
          CAS number571203-78-6
          FormWhite solid
          Hill FormulaC₃₀H₃₁ClN₄O₄
          Chemical formulaC₃₀H₃₁ClN₄O₄
          Structure formula Image
          Applications
          ApplicationErastin, CAS 571203-78-6, is a cell-permeable compound that binds to VDAC to alter its gating. Induces non-apoptotic cell death in tumor cells harboring activating mutations in RAS-RAF-MEK signaling.
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          329600

          References

          Reference overview
          Yagoda, N., et al. 2007. Nature 447, 864.

          Brochure

          Title
          Biologics 35.1
          Mitochondrial Metabolism Modulators
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-January-2008 JSW
          Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
          DescriptionA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number571203-78-6
          Chemical formulaC₃₀H₃₁ClN₄O₄
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesYagoda, N., et al. 2007. Nature 447, 864.