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AG340 | Epithelial Sodium Channel γ, control peptide for AB3534P

100 µg  
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      Replacement Information
      Catalogue NumberAG340
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionEpithelial Sodium Channel γ, control peptide for AB3534P
      OverviewENACgamma (Epithelial Sodium Channel gamma) control peptide for use with Catalog Number AB3534P. A 14 amino acid peptide sequence near the N-terminus of rat ENaC gamma.
      Alternate Names
      • ENaC gamma
      Product Information
      PresentationLiquid in PBS pH 7.4, containing 0.1% sodium azide.
      Key Applications
      • Cell Function Assay
      Application NotesAntibody blocking (AB3534P)


      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1 mg/mL
      Entrez Gene Number
      Gene Symbol
      • SCNN1G
      • SCNEG
      • Gamma-ENaC
      • ENaCg
      • Gamma-NaCH
      • ENaCgamma
      • PHA1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51170 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
      SIZE: 649 amino acids; 74270 Da
      SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
      SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.
      PTM: Phosphorylated on serine and threonine residues (By similarity). & Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).
      DISEASE: SwissProt: P51170 # Defects in SCNN1G are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
      SIMILARITY: SwissProt: P51170 ## Belongs to the amiloride-sensitive sodium channel family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 


      Reference overviewPub Med ID
      Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension.
      Kreutz, R, et al.
      Hypertension, 29: 131-6 (1997) 1997

      Show Abstract
      9039092 9039092
      Epithelial sodium channels: function, structure, and regulation
      Garty, H. and Palmer, L.G.
      Physiol. Rev., 77(2):359-396 (1997) 1997

      9114818 9114818
      Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel.
      Thomas, C P, et al.
      J. Biol. Chem., 271: 26062-6 (1996) 1996

      Show Abstract
      8824247 8824247
      Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel.
      McDonald, F J, et al.
      Am. J. Physiol., 268: C1157-63 (1995) 1995

      Show Abstract
      7762608 7762608
      Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel
      Voilley, N. et al.
      Genomics., 28(3):360-365 (1995) 1995

      7490094 7490094
      Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone.
      Lingueglia, E, et al.
      J. Biol. Chem., 269: 13736-9 (1994) 1994

      Show Abstract
      8188647 8188647
      Epithelial sodium channel related to proteins involved in neurodegeneration.
      Canessa, C M, et al.
      Nature, 361: 467-70 (1993) 1993

      Show Abstract
      8381523 8381523

      Data Sheet

      Epithelial Sodium Channel gamma, control peptide for AB3534P - Data Sheet