324688 Ellipticine - CAS 519-23-3 - Calbiochem

324688
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₄N₂ 519-23-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324688-10MG
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          10 mg
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          Description
          OverviewA cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
          Catalogue Number324688
          Brand Family Calbiochem®
          Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
          References
          ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
          Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
          Pommier, Y., et al. 1985. Biochemistry 24, 6406.
          Product Information
          CAS number519-23-3
          ATP CompetitiveN
          FormBright yellow solid
          Hill FormulaC₁₇H₁₄N₂
          Chemical formulaC₁₇H₁₄N₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targettopoisomerase 2
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUU8825000
          Safety Information
          R PhraseR: 23/24/25-40

          Toxic by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324688

          References

          Reference overview
          Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
          Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
          Pommier, Y., et al. 1985. Biochemistry 24, 6406.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-January-2013 JSW
          Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
          DescriptionA topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
          FormBright yellow solid
          CAS number519-23-3
          RTECSUU8825000
          Chemical formulaC₁₇H₁₄N₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 3548
          ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
          Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
          Pommier, Y., et al. 1985. Biochemistry 24, 6406.