504539 | Eliprodil - CAS 119431-25-3 - Calbiochem

504539
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₃ClFNO 119431-25-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04539.0001
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          Glass bottle 10 mg
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          Description
          OverviewA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, >100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for α1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain α receptors. Blocks neuronal voltage-gated Ca2+
          Catalogue Number504539
          Brand Family Calbiochem®
          SynonymsNMDA Antagonist IX, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
          References
          ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
          Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
          Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
          Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
          Product Information
          CAS number119431-25-3
          FormWhite solid
          Hill FormulaC₂₀H₂₃ClFNO
          Chemical formulaC₂₀H₂₃ClFNO
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>1, > 100, and > 100 →M for NR2B, NR2A, and NR2C, respectively.
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
          Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
          Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
          Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          SynonymsNMDA Antagonist IX, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
          DescriptionA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, > 100, and > 100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for ς1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain ς receptors. Blocks neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). A neuroprotective agent in acute ischemic stroke. Prolongs the QT interval in EKG.
          FormWhite solid
          CAS number119431-25-3
          Chemical formulaC₂₀H₂₃ClFNO
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (17 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
          Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
          Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
          Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.