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|324761-25MG||Glass bottle||25 mg||
|Overview||A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.).|
|References||Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.|
|Structure formula Image|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
Elastase Inhibitor V - Calbiochem SDS
|Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.|
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