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324759 | Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

324759
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₂N₂O₇S 127373-66-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324759-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
          Catalogue Number324759
          Brand Family Calbiochem®
          SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
          References
          ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
          Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
          Product Information
          CAS number127373-66-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₀H₂₂N₂O₇S
          Chemical formulaC₂₀H₂₂N₂O₇S
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetNeutrophil elastase
          Primary Target IC<sub>50</sub>19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324759

          References

          Reference overview
          Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
          Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          SynonymsN-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
          DescriptionA cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC50 = 5.6 µM) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number127373-66-4
          Chemical formulaC₂₀H₂₂N₂O₇S
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSuzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
          Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.