324745 Elastase Inhibitor III - Calbiochem

324745
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₅ClN₄O₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324745-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki = 10 µM). Protects against lung injury induced by instillation of elastase.
          Catalogue Number324745
          Brand Family Calbiochem®
          SynonymsHLE Inhibitor, MeOSuc-AAPV-CMK
          References
          ReferencesFletcher, D.S., et al. 1990. Am. Rev. Respir. Dis. 141, 672.
          Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
          Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₃₅ClN₄O₇
          Chemical formulaC₂₂H₃₅ClN₄O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHuman leukocyte elastase (HLE)
          Primary Target K<sub>i</sub>10 µM against human leukocyte elastase (HLE)
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceMeOSuc-Ala-Ala-Pro-Val-CMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324745

          References

          Reference overview
          Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis. 141, 672.
          Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
          Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-October-2007 RFH
          SynonymsHLE Inhibitor, MeOSuc-AAPV-CMK
          DescriptionA potent inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
          FormWhite solid
          Chemical formulaC₂₂H₃₅ClN₄O₇
          Peptide SequenceMeOSuc-Ala-Ala-Pro-Val-CMK
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFletcher, D.S., et al. 1990. Am. Rev. Respir. Dis. 141, 672.
          Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
          Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Elastase Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors