324622 Eg5 Inhibitor III, Dimethylenastron - CAS 863774-58-7 - Calbiochem

324622
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₈N₂O₂S 863774-58-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324622-1MG
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          Plastic ampoule 1 mg
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          324622-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC50 = 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
              Catalogue Number324622
              Brand Family Calbiochem®
              Synonyms7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
              References
              ReferencesLiu, M., et al. 2006. J. Biol Chem. in press.
              Gartner, M., et al. 2005. Chembiochem 6, 1173.
              Product Information
              CAS number863774-58-7
              ATP CompetitiveN
              FormLight yellow solid
              Hill FormulaC₁₆H₁₈N₂O₂S
              Chemical formulaC₁₆H₁₈N₂O₂S
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetMicrotubule-stimulated ATPase activity of the mitotic motor
              Primary Target IC<sub>50</sub>200 nM inhibiting the microtubule-stimulated ATPase activity of the mitotic motor, Eg5
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              324622

              References

              Reference overview
              Liu, M., et al. 2006. J. Biol Chem. in press.
              Gartner, M., et al. 2005. Chembiochem 6, 1173.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-April-2011 RFH
              Synonyms7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
              DescriptionA cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC50 = 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
              FormLight yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number863774-58-7
              Chemical formulaC₁₆H₁₈N₂O₂S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Harmful
              ReferencesLiu, M., et al. 2006. J. Biol Chem. in press.
              Gartner, M., et al. 2005. Chembiochem 6, 1173.