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328006 | ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

328006
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₆N₂O₃S • HCl 1049738-54-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      328006-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
          Catalogue Number328006
          Brand Family Calbiochem®
          Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
          References
          ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
          Product Information
          CAS number1049738-54-6
          ATP CompetitiveN
          FormLight yellow solid
          Hill FormulaC₁₄H₁₆N₂O₃S • HCl
          Chemical formulaC₁₄H₁₆N₂O₃S • HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetERK
          Primary Target IC<sub>50</sub>≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          328006

          References

          Reference overview
          Hancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
          DescriptionA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1049738-54-6
          Chemical formulaC₁₄H₁₆N₂O₃S • HCl
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.