328000 ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

328000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₈₆H₁₅₃N₁₉O₁₇S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      328000-1MG
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      Stocked 
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable and reversible stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 13 µM). Does not affect the activation of JNKs or p38.
          Catalogue Number328000
          Brand Family Calbiochem®
          SynonymsSte-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV
          References
          ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₈₆H₁₅₃N₁₉O₁₇S
          Chemical formulaC₈₆H₁₅₃N₁₉O₁₇S
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetMEK
          Primary Target IC<sub>50</sub>2.5 µM
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceSte-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          328000

          References

          Reference overview
          Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2010 RFH
          SynonymsSte-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV
          DescriptionA cell-permeable, reversible, and stearated, 13-amino acid peptide corresponding to the N-terminus of MAPK/ERK kinase (MEK). Acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of ELK1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). Shown to block ERK activity in PMA-stimulated NIH3T3 cells and NGF-treated PC12 cells (IC50 = 13 µM). Does not affect the activation of either JNKs or p38 MAP kinase.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₈₆H₁₅₃N₁₉O₁₇S
          Peptide SequenceSte-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.