324630 | EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

324630
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₂₃N₅O · HCl 51350-19-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324630-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
          Catalogue Number324630
          Brand Family Calbiochem®
          Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
          References
          ReferencesBurton, P., et al. 2010. Biochem. J. in press.
          Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
          Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
          Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
          Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
          Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
          Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
          Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
          Product Information
          CAS number51350-19-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₂₃N₅O · HCl
          Chemical formulaC₁₄H₂₃N₅O · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPDE 2
          Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
          Primary Target K<sub>i</sub>4 nM against adenosine deaminase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324630

          References

          Reference overview
          Burton, P., et al. 2010. Biochem. J. in press.
          Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
          Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
          Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
          Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
          Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
          Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
          Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-February-2012 RFH
          Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
          DescriptionThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
          FormWhite solid
          CAS number51350-19-7
          Chemical formulaC₁₄H₂₃N₅O · HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (25 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBurton, P., et al. 2010. Biochem. J. in press.
          Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
          Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
          Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
          Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
          Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
          Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
          Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.