324470 | E-4031 - CAS 113558-89-7 - Calbiochem

324470
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O 113558-89-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324470-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC50 = 7.7 nM).
          Catalogue Number324470
          Brand Family Calbiochem®
          Synonyms4ʹ-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
          References
          ReferencesFicker, E., et al. 2000. Am. J. Physiol. 279, H1748.
          Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
          Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
          Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
          Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
          Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
          West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
          West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.
          Product Information
          CAS number113558-89-7
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
          Chemical formulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibitor of the rapid type of inactivating inward-rectifying K+ current
          Primary Target IC<sub>50</sub>10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324470

          References

          Reference overview
          Ficker, E., et al. 2000. Am. J. Physiol. 279, H1748.
          Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
          Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
          Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
          Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
          Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
          West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
          West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.

          Citations

          Title
        • Jun Guo, Hongying Gang and Shetuan Zhang. (2006) Molecular Determinants of Cocaine Block of Human Ether-a-go-go-Related Gene Potassium Channels. Journal of Pharmacology and Experimental Therapeutics 317, 865-874.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-December-2016 JSW
          Synonyms4ʹ-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
          DescriptionA potent and selective inhibitor of the inactivating inward-rectifying potassium current (IK,IR) (IC50 = 10 nM). In inside-out patches, E-4031 also blocks ATP sensitive K+ channel (EC50 = 31 µM). A specific blocker of cardiac HERG channels (IC50 = 7.7 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity.
          FormWhite to off-white solid
          CAS number113558-89-7
          Chemical formulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml) or H₂O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFicker, E., et al. 2000. Am. J. Physiol. 279, H1748.
          Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
          Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
          Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
          Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
          Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
          West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
          West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.
          Citation
        • Jun Guo, Hongying Gang and Shetuan Zhang. (2006) Molecular Determinants of Cocaine Block of Human Ether-a-go-go-Related Gene Potassium Channels. Journal of Pharmacology and Experimental Therapeutics 317, 865-874.