322337 | Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

322337
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆₃H₂₅₆N₄₈O₃₇S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      322337-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC50 = 11 µM) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.
          Catalogue Number322337
          Brand Family Calbiochem®
          SynonymsAc-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH₂, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III
          References
          ReferencesZhang, Y., et al. 2009. Nat. Chem. Biol. 5, 217.
          Product Information
          FormLyophilized white solid
          FormulationSupplied as a trifluoroacetate salt
          Hill FormulaC₁₆₃H₂₅₆N₄₈O₃₇S
          Chemical formulaC₁₆₃H₂₅₆N₄₈O₃₇S
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          322337

          References

          Reference overview
          Zhang, Y., et al. 2009. Nat. Chem. Biol. 5, 217.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2010 RFH
          SynonymsAc-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH₂, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III
          DescriptionA 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC50 = 11 µM) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.
          FormLyophilized white solid
          FormulationSupplied as a trifluoroacetate salt
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆₃H₂₅₆N₄₈O₃₇S
          Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesZhang, Y., et al. 2009. Nat. Chem. Biol. 5, 217.