300260 | Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

300260
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₈ICl 4673-26-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      300260-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.
          Catalogue Number300260
          Brand Family Calbiochem®
          SynonymsDPI
          References
          ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
          Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
          Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
          Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
          Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
          Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
          Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.
          Product Information
          CAS number4673-26-1
          ATP CompetitiveN
          FormOff-white crystalline solid
          Hill FormulaC₁₂H₈ICl
          Chemical formulaC₁₂H₈ICl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargeteNOS
          Primary Target IC<sub>50</sub>180 nM against endothelial nitric oxide synthase (eNOS)
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 42/43-63

          May cause sensitization by inhalation and skin contact.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          300260

          References

          Reference overview
          Wang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
          Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
          Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
          Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
          Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
          Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
          Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          SynonymsDPI
          DescriptionA cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50 = 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system.
          FormOff-white crystalline solid
          CAS number4673-26-1
          Chemical formulaC₁₂H₈ICl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubility.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
          Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
          Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
          Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
          Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
          Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
          Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.