317641 | Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

317641
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₂₀N₄O₂ • HCl 866396-34-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      317641-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
          Catalogue Number317641
          Brand Family Calbiochem®
          Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
          References
          ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
          Product Information
          CAS number866396-34-1
          FormWhite solid
          Hill FormulaC₁₄H₂₀N₄O₂ • HCl
          Chemical formulaC₁₄H₂₀N₄O₂ • HCl
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          317641

          References

          Reference overview
          Wright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-November-2008 RFH
          Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
          DescriptionAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number866396-34-1
          Chemical formulaC₁₄H₂₀N₄O₂ • HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityEthanol (20 mg/ml), H₂O (20 mg/ml), or PBS (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.