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292505 | Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

292505
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₁₅N₃O₄ 213768-16-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      292505-1MG
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          Glass bottle 1 mg
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          Description
          OverviewAn esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol). Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.
          Catalogue Number292505
          Brand Family Calbiochem®
          References
          ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
          Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
          Product Information
          CAS number213768-16-2
          ATP CompetitiveN
          FormYellow liquid
          Hill FormulaC₇H₁₅N₃O₄
          Chemical formulaC₇H₁₅N₃O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetIntracellular nitric oxide (NO) donor
          Primary Target IC<sub>50</sub>8.3 µM, 53 µM, acting as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines, respectively
          Purity≥95% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          292505

          References

          Reference overview
          Kotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
          Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.

          Brochure

          Title
          Nitric Oxide Donors and Scavengers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2011 RFH
          DescriptionA cell-permeable O2-acetoxymethylated diazeniumdiolate that donates nitric oxide (NO) following the action of intracellular esterases (1.83 mol of NO/mol). Shown to induce apoptosis and act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation (~5 µM) in bovine aortic endothelial cells. Useful for temporal and spatial controlled NO availability.
          FormYellow liquid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number213768-16-2
          Chemical formulaC₇H₁₅N₃O₄
          Structure formula
          Purity≥95% by NMR
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
          Toxicity Standard Handling
          ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
          Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.