298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem

298711
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₁₀O₅ 1609-47-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      298711-100GM
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          Glass bottle 100 gm
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          298711-25GM
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              Plastic ampoule 25 gm
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              Description
              OverviewInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
              Catalogue Number298711
              Brand Family Calbiochem®
              SynonymsDiethyl Oxydiformate, DEPC
              References
              ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
              Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
              Product Information
              CAS number1609-47-8
              ATP CompetitiveN
              FormClear colorless liquid
              Hill FormulaC₆H₁₀O₅
              Chemical formulaC₆H₁₀O₅
              ReversibleN
              Applications
              Biological Information
              Primary TargetInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
              Purity≥97% by titration
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSLQ9350000
              Safety Information
              R PhraseR: 22-36/37/38

              Harmful if swallowed.
              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              298711

              References

              Reference overview
              Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
              Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision30-April-2008 RFH
              SynonymsDiethyl Oxydiformate, DEPC
              DescriptionInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
              FormClear colorless liquid
              CAS number1609-47-8
              RTECSLQ9350000
              Chemical formulaC₆H₁₀O₅
              Purity≥97% by titration
              SolubilityChloroform or Ethanol
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Toxicity Harmful
              Merck USA index14, 7998
              ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
              Blumbers, D.O. 1987. Methods Enzymol. 152, 20.