263200 | Dephostatin - CAS 151606-30-3 - Calbiochem

263200
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₈N₂O₃ 151606-30-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      263200-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewProtein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.
          Catalogue Number263200
          Brand Family Calbiochem®
          SynonymsPTP Inhibitor VII
          References
          ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
          Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
          Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
          Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
          Imoto, M., et al. 1993. J. Antibiot. 46, 1342.
          Product Information
          CAS number151606-30-3
          ATP CompetitiveY
          FormBrown powder
          Hill FormulaC₇H₈N₂O₃
          Chemical formulaC₇H₈N₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetprotein tyrosine phosphatase activity from human neoplastic cell line
          Primary Target IC<sub>50</sub>7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line
          Purity≥90% by HPLC
          SourceStreptomyces sp.
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCZ9021800
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          263200

          References

          Reference overview
          Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
          Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
          Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
          Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
          Imoto, M., et al. 1993. J. Antibiot. 46, 1342.

          Brochure

          Title
          Nitric Oxide Donors and Scavengers Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2008 RFH
          SynonymsPTP Inhibitor VII
          DescriptionProtein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.
          FormBrown powder
          Intert gas (Yes/No) Packaged under inert gas
          SourceStreptomyces sp.
          CAS number151606-30-3
          RTECSCZ9021800
          Chemical formulaC₇H₈N₂O₃
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityChloroform or DMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
          Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
          Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
          Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
          Imoto, M., et al. 1993. J. Antibiot. 46, 1342.