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253300 | Deltamethrin - CAS 52918-63-5 - Calbiochem

253300
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₉Br₂NO₃ 52918-63-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      253300-10MG
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          Glass bottle 10 mg
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          Description
          OverviewSynthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM). May also have varied effects on ion channels. Causes an increase in neurotransmitter release at synapses, and increases intrasynaptosomal Ca2+ levels.
          Catalogue Number253300
          Brand Family Calbiochem®
          Synonyms(S)-α-Cyano-3-phenoxybenzyl(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
          References
          ReferencesRichter, A., et al. 1995. Biochem. Pharmacol. 49, 367.
          Enan, E., and Matsumura, F. 1993. Biochem. Pharmacol. 45, 703.
          Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol. 43, 1777.
          Narahasi, T. 1992. Trends Pharmacol. Sci. 13, 236.
          Product Information
          CAS number52918-63-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₁₉Br₂NO₃
          Chemical formulaC₂₂H₁₉Br₂NO₃
          ReversibleN
          Structure formula Image
          Applications
          ApplicationDeltamethrin, CAS 52918-63-5, is a synthetic type II pyrethroid that acts as a potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 100 pM).
          Biological Information
          Primary Targetprotein phosphatase 2B
          Primary Target IC<sub>50</sub>100 pM against calcineurin (protein phosphatase 2B)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGZ1233000
          Safety Information
          R PhraseR: 21-23-28

          Harmful in contact with skin.
          Toxic by inhalation.
          Very toxic if swallowed.
          S PhraseS: 26-36/37/39-45-53

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid acid or alkali conditions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          253300

          References

          Reference overview
          Richter, A., et al. 1995. Biochem. Pharmacol. 49, 367.
          Enan, E., and Matsumura, F. 1993. Biochem. Pharmacol. 45, 703.
          Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol. 43, 1777.
          Narahasi, T. 1992. Trends Pharmacol. Sci. 13, 236.

          Brochure

          Title
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-December-2007 JSW
          Synonyms(S)-α-Cyano-3-phenoxybenzyl(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
          DescriptionSynthetic type II pyrethroid insecticide. Potent inhibitor of calcineurin (protein phosphatase 2B, IC50 = 100 pM). May also have varied effects on ion channels. Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels.
          FormWhite solid
          CAS number52918-63-5
          RTECSGZ1233000
          Chemical formulaC₂₂H₁₉Br₂NO₃
          Structure formula
          Purity≥98% by TLC
          SolubilityDMSO (15 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid acid or alkali conditions.
          Toxicity Highly Toxic
          Merck USA index14, 2883
          ReferencesRichter, A., et al. 1995. Biochem. Pharmacol. 49, 367.
          Enan, E., and Matsumura, F. 1993. Biochem. Pharmacol. 45, 703.
          Enan, E., and Matsumura, F. 1992. Biochem. Pharmacol. 43, 1777.
          Narahasi, T. 1992. Trends Pharmacol. Sci. 13, 236.